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Antioxidant Systems for Cardio-Vascular Issues


L.S. Mkhitaryan, M.D., professor, Scientific Research Institute of Cardiology attached to the Academy of Medical Sciences of Ukraine, Kiev.

In Russia, President Club Members attended a medical conference where distinguished Russian scientists presented their research on New Spirit Naturals' supplements. With this support, New Spirit Naturals has set the standard in the CIS States for product quality. The following is an excerpt from one such study on Cardiovascular Disease.

It is a proven fact that excessive free radical oxidation activity causes the onset and progression of such diseases as ischemic heart disease (IHD), essential hypertension, arrhythmia (cardiopalmus), etc. Excessively accumulated free radicals provoke peroxide modification of lipoproteins in the blood serum. As a result, they become more vulnerable to atherogenesis and the destruction of vascular walls may occur.

Consequently, these vascular walls become easily penetrated with lipids and various ions. Also, there is an increase of vascular tone (arterial hypertension), formation of atheros clerosis and changes in structure and electric properties of miocardia cell walls (imbalance of their excitability, conductivity and contractivity).

Excess of free radicals also make the body susceptible to thrombocytopoiesis, a condition that occurs after the destruction of cell walls and the breach of charge of trombocyte and erythrocyte surfaces that increases their adhesiveness and aggregability.

In order to avoid above mentioned ailments, the body "switches on" its antioxidant potential, a powerful force in defending the cells against free radicals and preventing the progression of disease. When prescribing a program of preventive measures for the treatment of cardio-vascular diseases, it is necessary to include nutritional supplements, natural antioxidants that serve as a "trap" for free radicals to assist the body's powerful defense mechanisms.

In our test, we observed: 78 out-patients with cardio-vascular diseases, including 26 with ischemic heart disease or angina of effort (I Ð II degree); 30 patients with hypertension (I Ð IIA degree) and 20 patients with arrhythmia (supraventricular tachyarrhythmia or extrasystolic arrhythmia).
All patients followed obligatory sanitary and preventive measures with the body cleansing step (1 coffee spoon of Nutri Cleanse 2 times a day during 1 month) followed by a balancing, restorative program of vitamins, minerals and intestinal flora using nutritional supplements including: Vita Balance 2000 (1 capsule 3 times a day), Jerusalem Artichoke Flour (currently not available) (1 tsp. 3 times a day), Magnum C (1 capsule 2 times a day). During second month of treatment, starting from the 3rd month, the patients received a complex of other synergistically acting nutritional supplements:
In the case of acute conditions, some patients in the beginning of the treatment continued to take doses of antianginal, antihypertensitive or antiarrhythmic pharmaceutical remedies. But as soon as their condition improved and cardio-vascular functions normalized, they stopped in favor of nutritional supplements only.

In addition to the general clinical and laboratory studies before and after treatment, we applied for each observed patient a study of indices that showed an activity of pro- and antioxidant systems of his or her body.
  • intensity of lipid oxidation (a concentration of diene conjugates and malonic dialdehyde were registered);
  • spontaneous hemaluminescence (the intensity of luminescence caused by presence and concentration of free radicals);
  • activity of antioxidant enzymes: catalase, superoxidismutase (SOD), glutathion reductase (GTR).
80% of patients from all 3 groups showed an activation of lipid peroxidation (there was increase of concentration of diene conjugates and malonic dialdehyde: 44% and 45% respectively in comparison to healthy persons). The same improved indices were in the intensity of hemaluminescence.

Simultaneously we registered a decrease of SOD and GTR activity (29% and 32% respectively) compared to control indices. Catalase activity had a tendency to decrease in the majority of patients, and 11 patients preserved it at the same control level.

Therefore, in cardio-vascular pathology there is an imbalance between pro- and antioxidant systems of the body. This imbalance is stipulated not only by the activation of lipid peroxidation, but also by significant depression of antioxidant enzyme systems that aggravates a pathogenic influence of free radicals in such conditions.

Within 1.5 to 2 months of treatment with nutritional supplements, patients showed normalization of lipid peroxidation activity (its decreasing). Indices showed a decrease of concentration of diene conjugates and malonic dyaldehyde (25% - 27% respectively) in comparison with indices before the treatment.

There was also a significant decrease of intensity of blood hemailuminescence (on average 31% ) that indicates the decrease of free radical concentration in the blood of patients. In the majority of patients, antioxidant enzymes normalized: there was an increase of activity of SOD and GTR (19 and 23% respectively) compared to the state before the treatment.

We saw the best clinical effect and dramatic improvement of the patient's state in the cases where the imbalance between pro- and antioxidant systems was decreased in maximum or eliminated. We should also note that normalization of pro- and antioxidant systems during this treatment corresponded to an improvement in the patients general physical state:
  • a normalization and stabilization of blood pressure;
  • a decrease of frequency of angina pectoris attacks;
  • a decrease of the amount of nitroglycerine required;
  • a normalization of blood prothrombin ratio.