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DHEA An Anti-Aging Dietary Supplement

Declining DHEA and the corresponding decline in dependent hormones has been linked to the loss of muscle tissue and stamina, fatigue, increased body fat, a decline in sex drive and an increased susceptibility to disease.

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At age 35, many individuals begin to fatigue more easily, experience a gradual loss of muscle mass and are not as effective at fighting off disease. Some of these changes are likely due to inactivity and life-style. The reality is that the aging process affects even those who watch their diet and exercise daily.

Although the specific mechanisms of action for DHEA are only partially understood, supplemental DHEA has been shown to have a positive influence on markers that define aging and obesity.

DHEA Replacement Therapy

Research indicates that DHEA replacement therapy can restore serum levels to those of a 21-year old. People over age 40 who do not supplement with DHEA usually have serum levels below 200, with many testing below 100. Chronic DHEA deficiency is a risk factor for developing the degenerative diseases of aging, according to the preponderance of evidence existing in scientific literature.

How do you know if you can benefit from DHEA?

You can test your current DHEA level. This may be done by your doctor and is helpful in establishing a base line to determine the effectiveness of supplementation. Since most adults over 40 have low DHEA blood levels, many health professionals feel that it is better to test DHEA blood levels three to six weeks after beginning supplementation to determine optimal dosing levels.

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A Summary of DHEA Studies (Watson, 1996)

For more detailed information on DHEA research select: DHEA Research

Selected References:

Arlt, W, CaRies, F, van Vlijmen, J C, et al, Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med. 1999 Sep30; 341(14): 1013-20.

Adrenal Insufficiency.NEnglJMed.I999Sep30;341(14): 1013-20. Danenberg, H D , Ben-Yehuda, A, Zakay-Rones, Z, Friedm8\, G, Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza 1IQccination and protects from influenza infection. Vaccine 1995; 13(15): 1445-8.

Genazzani, A D, et aI, Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women. Fertil Steril. 2001Aug; 76(2}: 241-8.

Herrington, D M, et al, Dehydroepiandrosterone and coronary atherosclerosis. Ann NY Acad Sci. 1995 Dec 29; 774: 271-8

Jesse,RL,et al, Dehydroepiandrosterone inhibits human platelet aggregation in vitro and in vivo Ann NY Acad Sci.I995 Dec 29; 774: 281-90

Khorram, O, et al, Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men. J Gerontol A BioI Sci Med Sci. 1997 Jan; 52(1}: MI-M7.

Simile, M, et al, Inhibition by dehydroepiandrosterone of growth and progression of persistent liver nodules in experimental rat liver carcinogenesis. Int J Cancer, 199,5 Jul 17; 62(2): 210-5.

Morales, A J, et al, Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age, J Clin Endrocrinol Metab, 1994 Jun; 78(6): 1360-7.

Morales, A J, et al, The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endrocrinol, 1998 Oct; 49(4): 421-32.

Watson, R R, et al, Dehydroepiandrosterone and diseases of aging. Drugs Aging. 1996 Oct; 9(4}: 274-91.

Van Vollenhoven, R F, et al, Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. J Rheumatol. 1998 Feb; 25(2): 285-9.

Journal of Endocrinology, Calcified Tissue International, March 2002.

DHEA, The Fountain of Youth , Journal of the Medical Assoc of Thailand, Oct, 2001.

Cherniske, S A, The DHEA Breakthrough, Ballantine Books.

Sahelain, R, DHEA: A Practical Guide, Avery Publishing.