Cruciferous vegetables such as broccoli sprouts, cauliflower, cabbage, and brussel sprouts contain a series of phytochemicals which react when the vegetable cell walls are broken by chewing, chopping, or juicing. Ic3 is just one of the many dietary indoles produced in this way. Icreasing consumption of these vegetables may be very beneficial to good health. DIM may promote healthy estrogen metabolism.
Epidemiological evidence overwhelmingly suggests that a diet high in fruits and vegetables is associated with a reduced risk of developing cancer
of the breast, cervix, bladder, esophagus, lung, colon, oral cavity, stomach, pancreas and ovary. One particular study concludes that, for
most cancer sites, persons with low fruit and vegetable intake (at least
the lower one-fourth of the population) experience about twice the risk
of cancer as compared to those with high intake, even after controlling
for potentially confounding factors.
Modern science has been able to identify some of the phytonutrients and
nutriceuticals found in fruits and vegetables that explain this predictable correlation between diet and disease prevention.
Research of particular interest in addressing the rising incidence of
breast cancer centers around the Crucifer (the Filseed family).
This botanical family is dominated by the genus Brassica which
includes the common cruciferous vegetables, including broccoli,
brussel sprouts, cauliflower, cabbage, bok choy, kale, rutabaga, turnips
and watercress.
These vegetables are the major source of glucosinolates
in the human diet. Glucosinolates are precursor structures until hydrolyzed
by the plant enzyme myrosinase, which is released from the vegetable cell
during the chewing process. Once hydrolyzed, glucosinolates form indoles,
isothiocynates, I3C, DIM and other related compounds.
2
eligs, Michael A., M.D., Diet and Estrogen Status: The Cruciferous Connection,
Journal of Medicinal Food Vol I, Number 2, 1998, p. 78.
Since the mid 1980s, there has been a growing body of literature
about the metabolites of steroid hormones, specifically the metabolites
of estrogen, and why some put us more at risk for cancer, while others
reduce the risk.
In the 1970s, Professor Henry Lemon, an oncologist at the University of
Nebraska, advanced the theory that estriol might provide protection
against cancer.
In addition to these epidemiologic observations, high estriol levels seem
to be protective against cancer in experimental animals.
Good Estrogen vs. Bad Estrogen
In the 1980s and 90s, a lot of research work centered around minor metabolites
of estrogens, specifically the metabolites 2-hydroxyestrone and 16-alpha-hydroxyestrone.
Dr. H. Leon Bradlow, of Rockafeller University, a leader in this field,
has called the 2-hydoxyestrone metabolite good estrogen, while
other researchers like Dr. Jonathan Wright, MD, have called the 16-alpha-hydroxyestrone
metabolite bad estrogen.
The 16- alpha version is labeled bad because it tends to damage
DNA and cause abnormal cellular proliferation. In a variety of animal
models, it is definitely associated with a higher risk of cancer and with
the progression of that cancer. In these same models, when the proportion
of 16-alpha-hydroxyestrone falls and 2-hydroxyestrone rises, the risk
of cancer and, therefore, its actual incidence, is reduced.
Fortunately, we now have urine test kits to measure the 2/16 OH Estrogen
Ratio. For additional information on these test kits, contact Dr. Milam
at 800-922-2766.
In addition, there are natural ways of altering this ratio in a positive
direction. Three substances, referred to as metabolic modifiers, are all
found in Brassica vegetables. (See Attached Chart)
1. I3C Indole-3-carbinol
There seems to be a growing list of what I3C does to modulate estrogen.
One of its most important actions is to change the way estrogen is metabolized.
Instead of transforming into 16-a-hydroxyestrone, estrogen is converted
to 2-hydroxyestrone (the weaker form of estrogen). When I3C is present,
a 50% reduction in 16- a-hydroxyestrone (bad estrogen) has
been achieved in one week. Women with more 2-hydroxyestrone than 16- a-hydroxyestrone
are at less risk for breast cancer.
Additional benefits that have been attributed to I3C include:
One of the most recent discoveries about indole-3- carbinol is that it
upregulates the tumor suppressor gene BRCA1 (Breast Cancer susceptibility
gene) through an estrogen receptor. BRCA1 is mutated in some cases of
breast cancer, especially in young women, and in some cases of prostate
and ovarian cancer. New Research shows that BRCA1 is not just a tumor
suppression gene, but has roles in DNA repair as well. This important
gene is found throughout the body. The newest findings indicate that the
I3C compound increases BRCA1 and works to block estrogen from sending
signals that enhance the growth of cancer. It was not known until recently
that I3C blocks the estrogen receptor alpha from being made. This is very
much like putting up a road block for estrogen. Even though it is present,
it cannot do harm.
2. DIM
In addition to I3C, cruciferous vegetables contain a dietary indole called
diindoylmethane or DIM. DIM is a naturally occurring dimer, or coupled
pair of I3C molecules. Early observations indicate that DIM is considerably
more potent in changing the 2/16-alpha-hydroxyestrone ratio and that there
is improved activity when I3C and DIM are used together.
Additional findings include:
3.
Ascorbigen
The third substance is perhaps the most common of the indoles found in
the Brassica vegetables and is the best researched. The name implies ascorbic
acid (vitamin C) and ascorbigen does indeed breakdown into ascorbic acid,
as well as I3C. Its primary benefit, however, is its generation of I3C
which improves the 2/16-alpha-hydroxyestrone ratio.
Research does appear to show that if we combine ascorbigen with I3C (the
way it occurs in nature), their effect is synergistic. Both of these compounds
are known as mixed-function oxidases, which helps render
carcinogens harmless before they cross the barrier to the lungs or bloodstream.
Together, I3C and ascorbigen have been observed to produce up to an 80
fold increase in intestinal mixed-function oxidase activity. (McDanell)
Ascorbigen is also known to operate as an immunomodulator or immune system
enhancer.
Other findings include:
In addition, Super Indoles-CVB by New Spirit Naturals includes
three additional powerful ingredients to enhance the formulation:
Brox-25
A broccoli powder standardized to 25% Dietary Indoles. Brox-25 includes
ascorbigen, diindolylmethane (DIM) and indole-3-carbinol (I3C). The degradation
products of these dietary indoles are considered beneficial and are the
same as those formed by digestion in the stomach.
CVB
This proprietary product is a cruciferous vegetable blend consisting of
Brassica olracea v. capitate, Brassica oleracea f. botrylis, Brassica
oleracea, along with Daucas carota and C. Limonum.
Vitamin C
Vitamin C is one of the best known antioxidants and, therefore, may inhibit
carcinogenesis. While still theoretic, it is believed that vitamin C may
inhibit carcinogenesis or tumor growth through a number of mechanisms:
Who should take Super Indoles-CVB?
This product helps promote healthy estrogen metabolism. Super Indoles-CVB
can help restore estrogen balance during perimenopause and can be used
in conjunction with hormone replacement therapy (HRT). It may also be
of benefit in women with various conditions and family histories, including
breast cancer, uterine or ovarian cancer, uterine fibroid tumors, fibrocystic
or painful breasts, cervical dysplasia and systemic Lupus Erythematosus
(SLE), fibromyalgia and PMS.
There has been less research conducted for men. However, it is speculated
that a mans prostate is as much at risk from a good/bad estrogen
ratio as it is from excess estrogen. In men, diminished estrogen metabolism
and estrogen accumulation are central problems associated with aging.
Along with a healthy diet and exercise, the metabolic shift to a younger
balance of testosterone to estrogen may be beneficial. Men are by all
means encouraged to eat cruciferous vegetables.
Why use this product
A dietary intake of 3 to 5 servings of vegetables, especially cruciferous
vegetables is recommended by the U.S.D.A. Dietary Guidelines for Americans.
Similar recommendations exist for most countries.
A few capsules can deliver the same dietary indole benefit as several
pounds of cruciferous vegetables.
Since Super Indoles-CVB contain the predominant dietary indoles
which result from the digestion of crucifer-ous vegetables and since many
people do not consume these vegetables daily, its use is recommended as
a dietary supplement.
Recommendations for use:
1. Take Super Indoles-CVB with food. This will improve absorption
and provide the best results.
2. Drink adequate water. Drinking 8 glasses of water a day is recommended
for good health. Restricting fluids while taking this product may be associated
with a darkening of the urine to a light brown color. This is analogous
to the change in urine color seen after eating asparagus. Drinking adequate
water will minimize this transient color change.
3. It is not recommended that you take Super Indoles-CVB with coffee
or tea. These beverages may compete with the metabolism of indoles.
For normal use, 1 capsule per day is suggested.
Super Indoles-CVB is a full spectrum blend of Dietary Indoles. One
capsule may be as effective as numerous capsules of other brands using
only one dietary indole. In general, taking the capsule with a meal that
contains some oil or fat may enhance absorption, as in the case of fat
soluble vitamins.
This product is not recommended for women who are pregnant or on birth
control pills, as it has not been studied in these special situations.