Super Indoles CVB
Help The Prevention of Cancer
Super Indoles CVB is a nutritional dietary supplement designed to promote normal, healthy estrogen metabolism and reduce the risk of some diseases, including cancer. This proprietary product contains a blend of phytonutrients and nutriceuticals (plant derived substances that are highly active physiologically). The primary ingredients are a group of phytochemicals extracted from the Brassica (cruciferous vegetables) known as: Indole-3-carbinol (I3C), D2M (Diindolymethane), ascorbigin, sulphoraphine, indoles, isothiocynates and glucosinolates.
Cruciferous vegetables such as broccoli sprouts, cauliflower, cabbage, and brussel sprouts contain a series of phytochemicals which react when the vegetable cell walls are broken by chewing, chopping, or juicing. Ic3 is just one of the many dietary indoles produced in this way. Icreasing consumption of these vegetables may be very beneficial to good health. DIM may promote healthy estrogen metabolism.
Epidemiological evidence overwhelmingly suggests that a diet high in fruits and vegetables is associated with a reduced risk of developing cancer
of the breast, cervix, bladder, esophagus, lung, colon, oral cavity, stomach, pancreas and ovary. One particular study concludes that, for
most cancer sites, persons with low fruit and vegetable intake (at least
the lower one-fourth of the population) experience about twice the risk
of cancer as compared to those with high intake, even after controlling
for potentially confounding factors.
Modern science has been able to identify some of the phytonutrients and nutriceuticals found in fruits and vegetables that explain this predictable correlation between diet and disease prevention.
Research of particular interest in addressing the rising incidence of breast cancer centers around the Crucifer (the Filseed family). This botanical family is dominated by the genus Brassica which includes the common cruciferous vegetables, including broccoli, brussel sprouts, cauliflower, cabbage, bok choy, kale, rutabaga, turnips and watercress.
These vegetables are the major source of glucosinolates in the human diet. Glucosinolates are precursor structures until hydrolyzed by the plant enzyme myrosinase, which is released from the vegetable cell during the chewing process. Once hydrolyzed, glucosinolates form indoles, isothiocynates, I3C, DIM and other related compounds.
eligs, Michael A., M.D., Diet and Estrogen Status: The Cruciferous Connection,
Journal of Medicinal Food Vol I, Number 2, 1998, p. 78.
Since the mid 1980s, there has been a growing body of literature about the metabolites of steroid hormones, specifically the metabolites of estrogen, and why some put us more at risk for cancer, while others reduce the risk.
In the 1970s, Professor Henry Lemon, an oncologist at the University of Nebraska, advanced the theory that estriol might provide protection against cancer.
In addition to these epidemiologic observations, high estriol levels seem to be protective against cancer in experimental animals.
Good Estrogen vs. Bad Estrogen
In the 1980s and 90s, a lot of research work centered around minor metabolites of estrogens, specifically the metabolites 2-hydroxyestrone and 16-alpha-hydroxyestrone. Dr. H. Leon Bradlow, of Rockafeller University, a leader in this field, has called the 2-hydoxyestrone metabolite good estrogen, while other researchers like Dr. Jonathan Wright, MD, have called the 16-alpha-hydroxyestrone metabolite bad estrogen.
The 16- alpha version is labeled bad because it tends to damage DNA and cause abnormal cellular proliferation. In a variety of animal models, it is definitely associated with a higher risk of cancer and with the progression of that cancer. In these same models, when the proportion of 16-alpha-hydroxyestrone falls and 2-hydroxyestrone rises, the risk of cancer and, therefore, its actual incidence, is reduced.
Fortunately, we now have urine test kits to measure the 2/16 OH Estrogen Ratio. For additional information on these test kits, contact Dr. Milam at 800-922-2766.
In addition, there are natural ways of altering this ratio in a positive direction. Three substances, referred to as metabolic modifiers, are all found in Brassica vegetables. (See Attached Chart)
1. I3C Indole-3-carbinol
There seems to be a growing list of what I3C does to modulate estrogen. One of its most important actions is to change the way estrogen is metabolized. Instead of transforming into 16-a-hydroxyestrone, estrogen is converted to 2-hydroxyestrone (the weaker form of estrogen). When I3C is present, a 50% reduction in 16- a-hydroxyestrone (bad estrogen) has been achieved in one week. Women with more 2-hydroxyestrone than 16- a-hydroxyestrone are at less risk for breast cancer.
Additional benefits that have been attributed to I3C include:
One of the most recent discoveries about indole-3- carbinol is that it upregulates the tumor suppressor gene BRCA1 (Breast Cancer susceptibility gene) through an estrogen receptor. BRCA1 is mutated in some cases of breast cancer, especially in young women, and in some cases of prostate and ovarian cancer. New Research shows that BRCA1 is not just a tumor suppression gene, but has roles in DNA repair as well. This important gene is found throughout the body. The newest findings indicate that the I3C compound increases BRCA1 and works to block estrogen from sending signals that enhance the growth of cancer. It was not known until recently that I3C blocks the estrogen receptor alpha from being made. This is very much like putting up a road block for estrogen. Even though it is present, it cannot do harm.
In addition to I3C, cruciferous vegetables contain a dietary indole called diindoylmethane or DIM. DIM is a naturally occurring dimer, or coupled pair of I3C molecules. Early observations indicate that DIM is considerably more potent in changing the 2/16-alpha-hydroxyestrone ratio and that there is improved activity when I3C and DIM are used together.
Additional findings include:
The third substance is perhaps the most common of the indoles found in the Brassica vegetables and is the best researched. The name implies ascorbic acid (vitamin C) and ascorbigen does indeed breakdown into ascorbic acid, as well as I3C. Its primary benefit, however, is its generation of I3C which improves the 2/16-alpha-hydroxyestrone ratio.
Research does appear to show that if we combine ascorbigen with I3C (the way it occurs in nature), their effect is synergistic. Both of these compounds are known as mixed-function oxidases, which helps render carcinogens harmless before they cross the barrier to the lungs or bloodstream.
Together, I3C and ascorbigen have been observed to produce up to an 80 fold increase in intestinal mixed-function oxidase activity. (McDanell) Ascorbigen is also known to operate as an immunomodulator or immune system enhancer.
Other findings include:
In addition, Super Indoles-CVB by New Spirit Naturals includes three additional powerful ingredients to enhance the formulation:
A broccoli powder standardized to 25% Dietary Indoles. Brox-25 includes ascorbigen, diindolylmethane (DIM) and indole-3-carbinol (I3C). The degradation products of these dietary indoles are considered beneficial and are the same as those formed by digestion in the stomach.
This proprietary product is a cruciferous vegetable blend consisting of Brassica olracea v. capitate, Brassica oleracea f. botrylis, Brassica oleracea, along with Daucas carota and C. Limonum.
Vitamin C is one of the best known antioxidants and, therefore, may inhibit carcinogenesis. While still theoretic, it is believed that vitamin C may inhibit carcinogenesis or tumor growth through a number of mechanisms:
Who should take Super Indoles-CVB?
This product helps promote healthy estrogen metabolism. Super Indoles-CVB can help restore estrogen balance during perimenopause and can be used in conjunction with hormone replacement therapy (HRT). It may also be of benefit in women with various conditions and family histories, including breast cancer, uterine or ovarian cancer, uterine fibroid tumors, fibrocystic or painful breasts, cervical dysplasia and systemic Lupus Erythematosus (SLE), fibromyalgia and PMS.
There has been less research conducted for men. However, it is speculated that a mans prostate is as much at risk from a good/bad estrogen ratio as it is from excess estrogen. In men, diminished estrogen metabolism and estrogen accumulation are central problems associated with aging. Along with a healthy diet and exercise, the metabolic shift to a younger balance of testosterone to estrogen may be beneficial. Men are by all means encouraged to eat cruciferous vegetables.
Why use this product
A dietary intake of 3 to 5 servings of vegetables, especially cruciferous vegetables is recommended by the U.S.D.A. Dietary Guidelines for Americans. Similar recommendations exist for most countries.
A few capsules can deliver the same dietary indole benefit as several pounds of cruciferous vegetables.
Since Super Indoles-CVB contain the predominant dietary indoles which result from the digestion of crucifer-ous vegetables and since many people do not consume these vegetables daily, its use is recommended as a dietary supplement.
Recommendations for use:
1. Take Super Indoles-CVB with food. This will improve absorption and provide the best results.
2. Drink adequate water. Drinking 8 glasses of water a day is recommended for good health. Restricting fluids while taking this product may be associated with a darkening of the urine to a light brown color. This is analogous to the change in urine color seen after eating asparagus. Drinking adequate water will minimize this transient color change.
3. It is not recommended that you take Super Indoles-CVB with coffee or tea. These beverages may compete with the metabolism of indoles.
For normal use, 1 capsule per day is suggested.
Super Indoles-CVB is a full spectrum blend of Dietary Indoles. One capsule may be as effective as numerous capsules of other brands using only one dietary indole. In general, taking the capsule with a meal that contains some oil or fat may enhance absorption, as in the case of fat soluble vitamins.
This product is not recommended for women who are pregnant or on birth control pills, as it has not been studied in these special situations.