Sleep Refresh Immune boosting. Benefits memory and attention span. Protects cardiovascular and brain function. Promotes mental clarity. Sleep restores the body and mind and helps us maintain our mental and physical health. Studies have reported the people who get seven to eight hours of sleep each night enjoy better health and live longer than people who get less sleep. Sleep Refresh helps re-balance an over active central nervous system to restore normal sleep patterns. 60 capsules Retail $39.95/ Your Cost $29.96

According to the U. S. Centers for Disease Control an estimated 83.6 million adults in the U.S. are sleep deprived and getting less than 7 hours of sleep. Seven hours is the minimum length of time that an adult should sleep in order to reduce health risks and early death. In addition, National Health and Nutrition Examination Survey reports that prescriptions for sleeping pills has risen from 2% in 1999 to 3.5% in 2010. These reports show the prevalence of sleep deprivation and the need for sleep.

Reasons Why We Have Trouble Speeping.

• Stress, Worry, Nervousness, Anxiety
• Medical Causes: Allergies, Asthma, Acid Re-flux, Arthritis, Chronic Pain, Sciatica, Restless leg syndrome, Sleep Apnea, Medications, Depression
• Lifestyle choices
• Jet lag and time zone changes
• Noise from internal or external sources
• Environmental discomfort – temperature or un-comfortable bedding
• Medications that interfere with sleep
• Napping longer than 20 minutes during the day or late in the day
• Caffeine later in the day, tobacco, or alcohol use
• Electronic device use in the evening-blue light represses melatonin
• Shift work
• Pets

Sleep Refresh Ingredients

Melatonin is a hormone primarily synthesized in the pineal gland, a small gland in the brain. Melatonin helps control your sleep and wake cycles. Very small amounts of it are found in foods such as meats, grains, fruits, and vegetables. Through the body's circadian rhythm it controls your natural cycle of sleeping and waking hours. In part, your body clock controls how much melatonin your body makes. Normally, melatonin levels begin to rise in the mid- to late evening, remain high for most of the night, and then drop in the early morning hours. Light affects how much melatonin your body produces. During the shorter days of the winter months, your body may produce melatonin either earlier or later in the day than usual. This change can lead to symptoms of seasonal affective disorder (SAD), or winter depression. Natural melatonin levels slowly drop with age. Some older adults make very small amounts of it or none at all. Sleep Refresh includes 1.5 milligrams of melatonin per capsules and can be used to treat jet lag or insomnia.

L-Theanine is an amino acid. L-Theanine is found to have a calming relaxing effect on the brain and it was included in Sleep Refresh to prepare a person for sleep. It relieves anxiety in part because it resembles the brain signaling chemical glutamate. While glutamate is an excitatory neurotransmitter, L-Theanine binds to the same brain cell receptors and blocks them to the glutamate's effects. L-Theanine pro-duces the opposite effect and becomes an inhibitory to the glutamate's effects, providing a calming and relaxing effect. L-Theanine also increases production of the inhibitory, relaxing neurotransmitter GABA, increasing the calming and anti-anxiety effects.

Valerian Root is a natural sleep aid. Historically, Valerian was used as a sedative-hypnotic agent for over 1000 years. It contains chemical compounds of arginine, glutamine, alanine, and GABA. Valerian root is widely used and respected by the general population and physicians for its sedative effects and anti-anxiety capabilities. Valerian extract can cause sedation by increasing your brain's GABA level. GABA is an inhibitory neurotransmitter and in large enough quantities it can cause a sedative effect. (5,6) Results from an in vitro study suggest that valerian extract may cause GABA to be released from brain nerve endings and then block GABA from being taken back into nerve cells. In addition, valerian's valerenic acid inhibits an enzyme that destroys GABA. (4) Studies indicate that valerian reduces the time it takes to fall asleep and improves the quality of sleep.

Chamomile is found in Europe and temperate regions of Asia. It has a long tradition as an herbal remedy to promote relaxation and calm-ness. Chamomile is often made into a tea and used in aromatherapy. Sedative effects are attributed to the flavonoids, including apigenin, which acts as a ligand for the central benzodiazepine receptors. Chamomile extract modulates GABA receptors and monoamine neuro-transmissions. A study investigating its effect on insomnia showed a small to moderate effect on sleep latency, night time awakenings, and fatigue severity scores. Overall, Chamomile is a safe herb with minimal side effects with a long history of use.

Passion Flower is a plant and studies have shown that it may be just as effective as synthetic drugs for generalized anxiety disorder. It has been used as a folk remedy for anxiety and insomnia since ancient times. The mechanism of action if thoughts to be related to the medication of the GABAergic system. In Sleep Refresh we have combined Passion flower with calming herbs such as valerian root and chamomile flowers.

References:

• Institute of Medicine Committee on Sleep M, Research. The National Academies Collection: Reports funded by National Institutes of Health. In: Colten H.R. Altevogt, B. M. eds. Sleep disorders and Sleep Deprivation: An Unmet Public Health Problem. Washington, D.C.: National Academies Press (US); National Academies of Sciences:2006.
• Cirelli, C. (2012) Brain plasticity, sleep and aging. Gerontology; 58(5):441-5.
• The effects of sleep deprivation on sleepiness, performance, stress, and immune system. Glas Srp Akad Nauka Med. 2009(50):111-23.
• Yoto, A., Motoki M, Murao S, et al. Effects of L-Theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol. 2012;31:28.
• Nathan, P.J., Lu K, Gray M, et al. The neuropharmacology of L-Theanine (N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30.
• Sarris, J. & Kavanagh, D.J. (2009). Kava and St. John's Wort: Current evidence for use in mood and anxiety disorders. Jour-nal of Alternative and Complimentary Medicine 17: 881-890.
• Santos M.S., Ferreira, F, Cunha, A.P, Carvalho A.P., & Macedo, T. (1994) An aqueous extract of valerian influences the transport of GABA in synaptosomes. Planta Medica 60: 278-279.
• Weeks, B. S., (2009). Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Med Sci Monit, 15(11): RA256-262
• Baek, J.H., Nierenberg, Kinrys, A. A., June, G. (2014). Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder. Australian & New Zealand Journal of Psychiatry; 48, Issue 8; 705 – 715. doi.org/10.1177/0004867414539198.
• Blumethal, M. (2003). The ABC Clinical Guide to Herbs. American Botanical Council. Austin, Texas.
• Awad, R., Levae D. Cybulska, P. et.al. (2007). Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Canadian Journal of Physiology and Pharmacology 85: 933-942.
• Zick, S. W. Wright, B. D., Sen. A, et. al. (2011). Preliminary examination of the efficacy and safety of standardized chamo-mile extract for chronic primary insomnia: A randomized placebo-controlled pilot study. BMC Complementary and Alternative Medicine; 11-78.