Anti-aging with AlphaCell

Scientific evidence now indicates that about 35% of the aging process is genetic. It is becoming increasingly apparent that we can control the remaining 65%. Unfortunately, most individuals do not know the steps necessary to mitigate the aging process. Moreover, many of our physicians are still unaware of scientific advances.

Yet the evidence is mounting: Some people live much longer than the expected 78 year life-span. Moreover, they look and act considerably younger than their chronological age. In fact, science can confirm that their biological age is far less than their chronological age. Biological age refers to how efficiently the body’s internal organs and repair mechanisms function. A younger Biological Age indicates the body has the ability to repair damaged cells and systems and renew itself.

To slow or reduce aging, our body must constantly replace billions of cells. When this is accomplished, we refer to the process as anabolic (building up) as opposed to catabolic (tearing down). To maintain our anabolic response, we must take control of a wide variety of nutritional factors.

Alpha-GPC is found naturally in some animal products and in vegetables, and it occurs naturally in the human body. For example, it is present in small quantities in liver, eggs and milk. Natural, unprocessed cow’s milk contains approximately 250 mg. of Alpha-GPC per liter.

AlphaCell PM uses concentrated Alpha-GPC from lecithin (soybeans). No animal products are used in the manufacturing process. This is of particular importance because of the potential for viral contamination in animal based Alpha-GPC.

Alpha-GPC is now considered an essential nutrient
Until recently, this nutrient was considered a nonessential nutrient, one the body could substitute with other naturally occurring compounds. In one human study, however, researchers found that choline was essential when excess methionine and folate were not readily available in the diet. (Zeisel, et. al, 1991) The National Academy of Science has recently acknowledged the need for dietary choline and established an Adequate Intake (AI) for this nutrient.

Choline serves as an essential component of phospholipids that constitute approximately 50% of the total mass of cell membranes. It contributes to the fluidity of cell membranes and is involved in processes such as membrane transport, enzymatic activity and cell signalling. (Biosynergy Tech Bulletin, 2001)

In both human and animal studies, researchers have found that age-related cognitive dysfunction is directly correlated to functional disturbances in cholinergic activity. (Coyle, et. al., 1983; Bartus, et. al., 1982)

Phosphatidylserine (PS)
A natural compound found in all cells, PS is most highly concentrated in the membranes of brain cells which make up about 70% of its nerve tissue mass. (Life Extension, 2002)

Left to its own devices, the brain will succumb to the insults of age, beginning with the fourth or fifth decade of life. Full mental capacity begins its decline as the production of PS slows to suboptimal levels. The net result of an aging brain is cognitive decline, including the gradual loss of the ability to learn, reason, concentrate and remember.

This vital anti-aging compound plays so many roles that a shortage often creates a variety of symptoms

Phosphatidylserine aids the storage, release and activity of many vital neurotransmitters and their receptors.
Phosphatidylserine aids in cell to cell communication
Phosphatidylserine is involved in the maintenance and restoration of nerve cell membranes.
Phosphatidylserine stimulates the release of dopamine, a mood regulator that also controls physical sensation and movement.
Phosphatidylserine increases the production of acetylcholine, necessary for learning and memory.
Phosphatidylserine enhances brain glucose metabolism.
Phosphatidylserine reduces cortisol levels (a stress hormone).
Phosphatidylserine boosts the activity of nerve growth factor (NGF) which oversees the health of cholinergic neurons.

Phosphatidylserine - Research Summary
Research has shown that dietary supplementation with Phosphatidylserine can slow and even reverse the decline of learning, mood, memory, concentration and word recall related to dementia or age-related cognitive impairment in middle aged and elderly subjects. (Kidd, 1999)

Study #1
In a multi-center Italian study, 87 test subjects aged 55 to 80 were assessed for the effects of Phosphatidylserine on senile mental deterioration. Subjects were given either 300 mg. Phosphatidylserine or a placebo for a period of 90 days. Improvements were noted in the Phosphatidylserine treated group with regards to cognitive functions such as attention, concentration and short term memory. Behavioral measurements also showed improvements in socialization, daily living, self-sufficiency and being more engaged with one’s environment. (Palmieri, 1987)

Study #2
In another study, 51 patients with Alzheimer’s disease were treated for 12 weeks with 300 mg. Phosphatidylserine There were significant improvements in several cognitive functions for the treatment group compared to those given a placebo. Differences were more dramatic among test subjects with less severe cognitive impairment, suggesting that Phosphatidylserine may be useful in the early stages of Alzheimer’s disease. (Crook,1992)

Taurine
During intense activity, the muscle fibers in the body manufacture this important amino acid from methionine and cysteine. Taurine is present in the developing brain of infants in amounts four times higher than in adults. Taurine is such a critical nutrient that its level is mandated in infant formulas. Animal studies have shown that a taurine deficiency occurs with advanced age, particularly in females since estradiol depresses taurine production in the liver.

Benefits from adding supplemental taurine to the diet:

Taurine functions as a neurotransmitter in the brain and retina
Taurine exhibits antioxidant properties, so much so that white blood cells remain inactive unless taurine is present to neutralize the radical oxygen species they generate when responding to invading bacteria.
Taurine aids in reducing the occurrence of congestive heart failure
Taurine improves heart arrhythmia
Taurine exhibits insulin-like effects on blood sugar (Compound Solutions, 2002)

A taurine deficiency can often be traced to a vegetarian diet or reduced animal protein intake. Taurine is not found in sufficient amounts in vegetable protein. Taurine is also associated with increased physical stress and exercise.

L-Glutamine
L-Glutamine is the most abundant amino acid in the body. In skeletal muscle, l-glutamine makes up more than 60% of the free amino acid pool. L-glutamine has become a popular nutritional supplement for athletes and body builders, as well as for individuals with chronic illness or unintentional weight loss. L-Glutamine enhances the body’s nutritional status by promoting a positive nitrogen balance, conserving muscle mass and promoting glycogen synthesis.

Because decreased l-glutamine levels have been observed in many stressful disease states, experts are suggesting that l-glutamine be classified as a conditional essential nutrient. There are numerous benefits of supplementing with this important nutrient:

L-Glutamine produces anabolic (muscle building) effects in humans and animals
L-Glutamine stimulates protein synthesis
L-Glutamine inhibits protein breakdown
L-Glutamine helps increase muscle mass
L-Glutamine assists in exercise recovery
L-Glutamine supports immune function

Causes of l-glutamine deficiency include severe trauma, infection or metabolic stress induced by a catabolic state or extreme physical exertion.

Lysine
This essential amino acid cannot be synthesized by the body and must be consumed in the diet. As with all of the ingredients in this extraordinary product, the benefits of supplementing with lysine are many.

Lysine helps in the absorption of calcium in the intestinal tract
Lysine promotes bone growth
Lysine is important in the formation of collagen, the basic matrix of the connective tissues, skin , cartilage and bone l It may help prevent osteoporosis through enhancing the absorption and utilization of calcium (Hass, 1992)

Lysine and methionine help create an amino acid metabolite called l-carnitine which, in turn, transports fatty acids into the mitochondria where they are converted to energy. (Schoenhals, 1992).

L-Selenomethione (Selenium)
Exciting research on selenium during the past few years have elevated it to an “essential” status. Some studies show that low soil levels of selenium are associated with higher cancer rates, particularly cancers of the breast, colon and lungs.

Soil levels vary greatly from state to state and from country to country throughout the world. Consequently, the amount of selenium in our food sources varies according to where the food supply is grown. In addition, most selenium in foods, such as flour and rice, is lost during processing. The average intake of selenium in America is about 108 mcg. (Colgan, 1995)

Benefits of supplementing with selenium:

Selenium serves as an antioxidant in the enzyme selenium-glutathione peroxidase
Selenium helps protect cells and membranes from lipid peroxidation
Selenium helps protect us from the toxic effect of heavy metals
Selenium aids in protein synthesis, and enhances fertility and growth and development
Selenium helps improve sperm production and motility (Haas, 1992, p. 213)

References
Abbiati, C, Rondi, G, Rosola, R, Vavassori, F, Bosio, A, Nootropic Therapy and Cerebral Aging. Advances in Therapy, 8:6 1991: 268-276.

Aleppo, G, Nicoletti, F, Sorino, M A, Casabona, G, Scapagnini, U, Canonico, P L, Chronic L-alpha-glycerylphosphorylcholine increases inositol phosphate formation in brain slices and neuronal cultures. Pharmacol Toxicol, Feb: 74(2) 1994:95-100.

Bartus, R T, Dean R L, Beer, B, Lippa, A, The Cholinergic Hypothesis of Geriatric Memory Dysfunction, Science: 217 1982: 408-417.

BioSynergy Technical Bulletin, 2001.

BioSynergy Technical Bulletin, The Mind Issue, Alpha-GPC, 4: Spring 1999.

Ceda, G P, Ceresini, G, Denti, L, Marzani, G, Piovani, E., Banchini, A., Tarditi, E., Valenti, G., Alpha glyceryl phosphorylcholine administration increases the GH response to GHRH of young and elderly subjects. Horm Metab Res. March: 24(3) 1992:119-121.

Colgan, Michael, The New Nutrition, Medicine for the Millennium. Apple Publishing, 1995:96.

Coyle, J R, Price, D L, Delong, M R, Alzheimer’s Disease., A disorder or cortical cholinergic innervation, Science 219 1983:1184-1190.

Crook, T, et. al., Effects of PS in Alzheimer’s Disease. Psychopharmacol Bull. 28:1 1992:11-66, Endocrinol Invest. , Feb 17:2 1994:113-117.

Govini, S, Lopez, C M, Battaini, F, Trabucci, M, Chromic treatment with an acetylcholine synthesis precursor, alpha-glycerylphosphorylcholine, alters brain parameters linked to cholinergic transmission and passive avoidance behavior. Drug Development Research, 26:4 1992:439-447.

Hass, Elson, M., Staying Healthy with Nutrition, Celestial Arts, Berkley, Ca. 1992:213.

Karezma, A G, 1979 Overview: Cholinergic drugs and behavior - what effects may be expected from a cholinergic diet. In Nutrition and the Brain, ed. A. Barbeau, J Grouden, R Wurtman, New York Review 5:141-75.

Kidd, A Review of Nutrients and Botanicals in the Integrative management of Cognitive Dysfunction. Alternative Medical Rev. June: 4:3 1999;44-61.

Palmieri, G, et. al. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration, Cln. Trials J. 24 1987:73-83.

Schoenhals, Kim, Performance Nutrition, Nutritional Products Industry Insider May 2002:48.

Trabucchi , M, Govoni, S, Battaini, F, Changes in the interaction between CNS Cholinergic and dopaminergic neurons induced by L-alphaglycerylphosphorylcholine, a cholinomimetic drug. Farmaco Edizone Scientifica, 41:4 1986: 323-334

Zeisel, S H, DaCosta, K A, Franklin, P D, Alexander, E A, Lamont, J T, Sheard, N F, Beiser, A, Choline, An Essential Nutrient for Humans, The BASEB Journal, Apr 5:7 1991:2093-2098.

Anti-aging with AlphaCell™

Staying Young with Alpha Cell™

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